Dosing and Administration
Dosing
- Vaprisol is indicated for intravenous (IV) use in hospitalized patients only
- Therapy should begin with the administration of a loading dose of Vaprisol 20 mg IV as a 30-minute infusion, followed by a 20-mg continuous infusion administered over 24 hours
- Vaprisol should be administered intravenously for an additional 1 to 3 days as a continuous infusion of 20 mg/day; the total duration of Vaprisol (after loading dose) should not exceed 4 days
- Vaprisol may be titrated up to a maximum dose of 40 mg daily if serum sodium concentration is not rising at the desired rate
Administration and monitoring
- Serum sodium, volume, and neurological status must be carefully monitored
- Limit rise in serum sodium to <12 mEq/L/24 h
- In patients whose serum sodium rises undesirably rapidly, Vaprisol should be discontinued and serum sodium concentration and neurological status carefully monitored; if serum sodium continues to rise, Vaprisol should not be resumed
- Administer Vaprisol through large veins, and change the infusion site every 24 hours to minimize the risk of vascular irritation
Preparation
Download the file below for convenient instructions on how to prepare Vaprisol for administration. Also included is a summary of the dosing, administration, and monitoring instructions, as well as a reminder of the key benefits that Vaprisol can provide.
Download a printable PDF of the Vaprisol Dosing Instructions here*
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