Dosing and Administration
Accurate premixed IV formulation
- Vaprisol does not require dilution and has a well-defined daily dose (10 mg, 20 mg, and 40 mg)1
- Vaprisol does not require the use of a complicated formula, which can be susceptible to human error
Convenient administration
- Therapy should begin with a loading dose of Vaprisol 20 mg IV administered over 30 minutes, followed by a
20-mg continuous IV infusion administered over 24 hours1 -
— Therapy should be administered through large veins and infusion site changed every 24 hours
to minimize the risk of vascular irritation1 - Vaprisol should be administered for an additional 1 to 3 days as a continuous IV infusion of 20 mg/day; the total duration of Vaprisol (after loading dose) should not exceed 4 days1
- May be titrated up to a maximum dose of 40 mg/day if serum sodium concentration is not rising at the desired rate1
- Packaged in single-use, ready-to-use containers—can be stored in drug-dispensing units1
- Maintain at room temperature and protect from light until ready for use
- 30-month shelf life1
- Use in hospitalized patients only
- Serum sodium concentration, volume status, and neurological status must be carefully monitored
- Limit rise in serum sodium concentration to ≤12 mEq/L/24 hours
- Discontinue Vaprisol in patients whose serum sodium concentration rises undesirably rapidly; if serum sodium concentration continues to rise, Vaprisol administration should not be resumed
- The flexible container is for single use only—any unused portion should be discarded
- Vaprisol has been shown to be incompatible with both Lactated Ringer's Injection and furosemide injection when these products are mixed in the same container; therefore, do not combine Vaprisol with these products in the same intravenous line or container
Specific populations (hepatic impairment)1
In patients with moderate hepatic impairment, initiate Vaprisol with a loading dose of 10 mg over 30 minutes followed by a continuous infusion of 10 mg over 24 hours for 2 to a maximum of 4 days. If serum sodium is not rising at the desired rate, Vaprisol may be titrated upward to 20 mg over 24 hours.
